Second Nature Care Blog

5 steps to a Good Gut

[fa icon="calendar'] May 10, 2017 6:38:40 AM / by Isadora Guggenheim

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Keep the monarch butterflies and gut microbiome diversity alive with 5 steps to a GOOD GUT. Celiac awareness and education has helped millions of patients and practitioners to understand the "celiac piece."  UK children diagnosed with celiac has tripled over the past twenty years except for those lower on the economic ladder.  Diagnosis has increased for boys and girls.  

We test all patients for celiac disease, celiac genetics and individual food allergies in CT.  I've found patients in their 70's with full-blown celiac disease. Have you been tested?

Second Nature Care GOOD GUT Programs

We have excellent programs to heal leaky gut and reverse autoimmune conditions. 

Does the introduction of gluten into an infant's diet increase the risk of developing celiac disease?

Previous studies pointed to age of first gluten exposure, duration of breastfeeding and other factors to cause disease onset.  

Researchers found the timing of gluten introduction into the diet was not linked to celiac disease. They found an increased risk for celiac disease in infants who breast-fed more than 1 month after gluten was introduced compared to those who stopped breast-feeding before gluten was introduced. 

My clinical response to this situation will be "Keep breastfeeding and avoid all gluten." There is some relationship between the two that has not been identified. Recent studies have shown if you are going to introduce gluten it is best introduced earlier during breastfeeding. 

The last frontier in medicine - Microbiome 

The intestinal microbiome is huge and big business is partnering up to create an intestinal microbiome drug to inhibit autoimmune diseases. Johnson and Johnson teamed up with Vedanta Biosciences (microbiome company) to develop drugs that control key immune cells to turn off autoimmune diseases.   

What is the difference between intestinal barrier and intestinal permeability?  

The intestinal barrier is the mucosal surface where billions of bacteria thrive and trillions of genes hang out. The barrier is supposed to protect us from pathogens and toxins.  It must be able to absorb fluids and nutrients. Those two functions lead us to intestinal permeability. If you have a chronic disease you have increased intestinal permeability which allows intestinal cells and foreign proteins into the bloodstream. This tissue translocation causes inflammation. 

Microbiome factoids

Intestinal cells renew every 5 days. We have 4 cell lines in the gut. Enterocytes, enteroendocrine cells that secrete hormones, mucus-producing globlet cells and Paneth cells (only found in the human small intestine). Paneth cells produce several anti-microbial factors to protect you from infection.  

Cells can shed rapidly and create a defective opening which allows pathogens and foreign proteins to enter the bloodstream and cause inflammatory responses.  

The microbiome is a dynamic and robust mechanism that renews, repairs, protects and keeps us healthy. Our microbiota breaks down and absorbs nutrients, produces vitamins, secretes hormones and prevents pathogenic colonization. Our intestinal microbiome prevents the loss of water and electrolytes and prevents foreign microorganisms into the body and allows nutrients into the cells.

The intestinal barrier uses 40% of the body's energy.

The microbiome is two layers - an outer physical barrier and and inner immune functional layer.

The intestinal wall has four layers - mucosa, submucosa, muscularis and serosa.

Our intestines has a single layer of epithelial cells that create a physical barrier between the inside of our intestine and our mucosal tissues. Tight junctions seal the paracellular space so water and smaller molecules can move in and out. Beneath the tight junctions are adherence junctions which control cell-to-cell signaling between intra-membrane proteins like: occludin, claudin and tricellulin.  Cells are linked together by these proteins. Everything is linked together with scaffolding proteins - Zonula occludens.

If all three proteins, occludin, claudin and tricellulin, are damaged or disturbed then the tight junction proteins that create a tight seal are breeched and you get "leaky gut." Zonula occludens proteins link the cell cytoskeleton to the transmembrane tight junction proteins.  Zonula occluden proteins are markers that I test to prove if a patient has leaky gut.  Serotonin goes low and histamine goes high with leaky gut. 

Leaky gut is linked to all chronic diseases. 

We offer DunWoody Lab testing; the only lab in the country that does zonulin testing. 

Humans and mammals produce large amounts of secretory IgA to protect us against pathogens. Our secretory IgA lives with our normal gut flora.  It binds to viruses, bacteria and fungi to prevent adhesion to the gut wall and invasion of the mucosa.  

We have several hundred species of gut bacteria and most fall into two dominant families or phylum - Bacteroidetes and Firmicutes.

What damages our microbiome? Alcohol, Western diet, trauma, lack of exercise, dehydration, genetic differences, pathogens (bacteria, viruses, fungi), heavy metals, GMO's genetically modified organsims, pesticides and other nonxious chemicals.

What can you do to get a GOOD GUT?

  1. Change your diet today.  Most of my patients remove grains, diary, sugar, alcohol, nightshades and reactive foods. I have advanced food allergy and food sensitivity testing available. If you remove the basic suspects your gut will heal faster. Patients reverse their autoimmune conditions in 21 days when they remove all food and use Xymogen's OptiCleanse GHI Sugar and Stevia Free, GlutAloeMine, IgG26DF and OptiFiber SCFA.
  2. Take daily prebiotics and probiotics.  My GoodGut products are my choice, of course.
  3. You need Vitamins A and D.  Both regulate the growth and differentiation of intestinal cells. You are more susceptible to infections if you are deficient in A and D. Deficiency of A changes your gut bacteria, the amount and quality of mucus and lowers your defense molecules. Vitamin D deficiency correlates to the severity of Inflammatory Bowel Disease.
  4. You need SCFA short chain fatty acids. I recommend Xymogen's OptiFiber SCFA.
  5. Butyrate, Glutathione, Glutamine and Histamine Dioxidase are key players to restoring your GOOD GUT. I recommend S-Acetyl Glutathione, GlutAloeMine and HistDao from Xymogen and Butyrate from Neesby.  HistDao must be taken twice a day and inbetween meals for the best therapeutic effect.  

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Isadora Guggenheim

Written by Isadora Guggenheim

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Isadora Guggenheim, ND, RN, MS, CNS LMT, owner of Second Nature Naturopathic Care, LLC
For all appointments: Tel: 845 358-8385 Fax: 845 358-2963 drguggenheim@msn.com