Second Nature Care Blog

Autoimmune Disorders and Genomics - 2018 Reverse Your Autoimmune Condition - I.V. Ozone 

[fa icon="calendar'] Jan 11, 2018 9:45:50 PM / by Dr. Isadora Guggenheim

Genomic defects are linked to autoimmune diseases

Do you have periodic fevers or weird immune responses with generalized inflammation?  You might have a mutation in your NLRC4 gene.  There is always new information on the autoimmune front.  Researchers have linked autoinflammatory syndromes to NLRC4 gene mutations.  Mutations in this gene are similar to NLRP3 gene mutations. NLRP3 encodes the cryopryrin protein which is part of a multi-protein complex called inflammasome.   

Over 30 million women are dealing with an autoimmune condition like rheumatoid arthritis, Lupus, Sjogren's, Hashimoto’s thyroiditis, inflammatory bowel disease, celiac sprue, endometriosis, PCOS and type 1 diabetes. It is projected that one in nine women between the ages of 20 to 45, will be diagnosed with an autoimmune disease! This can be changed and with my credentials of environmental medicine, naturopathic medicine, cancer care, master's in nutrition, ozone expertise, I.V. nurse and nurse practitioner; I have the knowledge base and clinical skills to empower your health. Wouldn't it be great to feel good again and see your labs in the normal range? It can be done.

Inflammasome detects immune system danger signals when another protein gets activated. Proinflammatory proteins called interleukin 1 and 18 are produced in high levels and these interleukins cause a variety of symptoms like: fevers, aseptic meningitis, joint pain and rashes.  

Labs can show high C-reactive protein, high levels of ferritin (long term iron storage), low NK or natural killer cells and high triglycerides without any infectious cause. We partner with Empire City Labs so we can run comprehensive panels in order to identify underlying root causes of your condition. We can determine how and why the system is out of balance, what systems are affected and look at your genomics to individualize your treatment.  

Why is this important?

NLRC4 gene variation has gastrointestinal manifestations whereas NLRP3 does not.  It's also important because babies can be born with autoinflammatory conditions that present with fever, vomiting, rash, enlarged spleen and show no confirmatory signs of infection. Autoimmune diseases such as: juvenile arthritis, enterocolitis and systemic lupus are part of this syndrome.  

Naturopathic medicine has colchicine formulas and natural corticosteroids to control symptom flares. Serious acute cases need hospitalization as left untreated high serum ferritin levels, low NK cells can cause organ failure and death.  

I see autoimmune patients with dysregulated genes and systemic inflammatory flares.  I can't change your genes, but I can change how your genes respond to your internal environment. I consider your intestinal microbiome and your genomics. Changing your gut bacteria can down or upregulate greater systemic networks all over the body. Together, we can turn your "dirty genes" off. 

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Using GOOD GUT products is your first step to reversing your autoimmune condition.   



Topics: Autoimmune Disease, Healthy Living

Isadora Guggenheim, ND, RN, MS, CNS LMT, owner of Second Nature Naturopathic Care, LLC
For all appointments: Tel: 845 358-8385 Fax: 845 358-2963