Second Nature Care Blog

Berberine - Naturally Treating PTSD - Xymogen - Naturopathic Medicine

[fa icon="calendar'] Apr 10, 2018 4:15:05 PM / by Winter Ninivaggi


Have you tried Berberine? An all natural alkaloid found in the goldenseal root, barberry bark, Oregon grape root and coptis root.

An all natural alkaloid found in the goldenseal root, barberry bark, Oregon grape root and coptis root.A new study reported significant anti-stress effects of Berberine to add to its numerous healing properties. It has been known to improve type-2 diabetes, blood lipid levels, lower blood pressure and benefit the intestinal microbiome.

"Since the early 1900's, purified Berberine has been used as a popular natural medicine especially in China. Scientific research has focused on in the last decade is building an impressive amount of clinical research in the use of berberine in lowering blood lipids and blood pressure and improving blood sugar control in type 2 diabetes. Berberine exhibits a number of beneficial mechanisms to produce these effects including: an ability to activate the important enzyme called AMP-activated protein kinase or AMPk for short. AMPk is found inside every cell and serves as a “master regulating switch” in energy metabolism. " (Murray, 2018)

Berberines increase your body's adaptation to cold exposures by generating more heat and burning more calories.  Berberines activate key fat-burning genes. PGC-1-alpha estrogen-related receptor alpha, nuclear respiratory factor 1, CIDEA, COX8band, Isdp5 and UCP1 transciption were all strongly induced for the biochemically-minded.  Berberines allowed less dietary lipids to accumulate in brown fat and the number of mitochondria (organs that produce energy) increased after berberine treatment.  

Low AMPk properties include: accelerated aging, chronic inflammation, high blood cholesterol, increased belly fat, insulin resistance, mitochondrial insufficiency and dysfunction, neurodegeneration, obesity and poor blood sugar control.

Berberine has a variety of mechanisms that improve the composition of the microbiome appearing to treat gastrointestinal infections. Effective against diarrheas caused by a number of parasites and infectious organisms such as: E. coli (traveler’s diarrhea), Shigella dysenteriae (shigellosis), Salmonella paratyphi (food poisoning), B. Klebsiella, Giardia lamblia (giardiasis), Entamoeba histolytica (amebiasis), and Vibrio cholerae (cholera). (Murray, 2018)

PTSD can develop in response to traumatic or life-threatening events, causing anxiety, fear and nightmares. PTSD is the result of powerful memories of extreme fear response. "Researchers at a major university in Seoul, South Korea, found that berberine may be useful for treating drug addiction, such as cocaine and morphine, and through this mechanism thought it might also be helpful in PTSD." (Murray, 2018)

We have the best berberine formula at Second Nature Care! 

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Murray, M., ND. (n.d.). Berberine corrects brain chemistry in anxiety and PTSD. Retrieved April 05, 2018, from

Winter Ninivaggi

Written by Winter Ninivaggi

Isadora Guggenheim, ND, RN, MS, CNS LMT, owner of Second Nature Naturopathic Care, LLC
For all appointments: Tel: 845 358-8385 Fax: 845 358-2963