Second Nature Care Blog

Endometriosis and Breast Cancer - Quiz

[fa icon="calendar'] Nov 28, 2016 5:00:00 AM / by Isadora Guggenheim & Winter Ninivaggi

Endometriosis and Breast Cancer.

Endometriosis can affect up to 10% of women.  It is an autoimmune condition that causes severe pain,insomnia, irritability, depression, painful bowel movements and infertility. Cells in the uterus move outside of the womb and implant on other pelvic structures causing tremendous inflammation. 

The pain can be debilitating.  Now we offer a three pronged approach to treating endometriosis so that you can become pain-free and get quality of life back.

 

1. True or False. Endometriosis affects more than 23% of women of reproductive age.

A. True
B. False

2.  Which of the following statements is/are most accurate about the association between endometriosis and breast cancer?

A. They share risk factors such as body size, age at menarche, and parity
B. Many of the treatments for endometriosis may alter breast cancer risk
C. A and B

3. A prospective cohort study investigated the association between self-reported, laparoscopically confirmed endometriosis and the risk of breast cancer and found that women with endometriosis were NOT at a higher risk for:

A. Overall breast cancer
B. Premenopausal breast cancer
C. Postmenopausal breast cancer
D. A, B or C

4. True or False. In the same prospective cohort study, an increased risk of estrogen- and progesterone receptor-positive (ER+/PR+) tumors and ER- and PR- tumors was observed in women with endometriosis.

A. True
B. False

5. Women with endometriosis were found to be at a nearly __________ increased risk of ER+/PR- breast cancers compared with women without endometriosis.

A. Twofold
B. Fourfold
C. Sixfold

 

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Answer Key :

1. B. False - According to information cited in Obstetrics & Gynecology, “[e]ndometriosis is a painful and debilitating gynecologic condition defined by the presence of endometrial-like tissue outside the uterus. This chronic disorder affects 6–10% of women of reproductive age in the United States and is the third leading cause of gynecologic hospitalization, yet it's etiology and relationship to the risk of other diseases, including breast cancer, remain unclear.”

2. C. A and B - According to information cited in Obstetrics & Gynecology, the “potential association between endometriosis and breast cancer is complex. Both diseases have been hypothesized to be associated with an abnormal hormonal environment and increased inflammation. Endometriosis and breast cancer also share many risk factors such as body size, age at menarche, and parity. Additionally, many of the treatments for endometriosis, including oral contraceptives, analgesic use, and oophorectomy, may alter breast cancer risk.”

3. D. A, B or C - According to a prospective cohort study published in Obstetrics & Gynecology, “[a]t baseline, 5,389 (5%) women reported laparoscopically confirmed endometriosis. Over 24 years of follow-up, 4,979 (3%) incident breast cancer cases were diagnosed. Women with endometriosis were not at higher risk for overall (adjusted HR 0.96, 95% CI 0.88– 1.06), premenopausal (adjusted HR 1.05, 95% CI 0.89–1.23), or postmenopausal breast cancer (adjusted HR 0.93, 95% CI 0.80–1.07).” This prospective cohort study included women from the Nurses’ Health Study II between 1989 until 2013.

4. B. False - According to a prospective cohort study published in Obstetrics & Gynecology, “associations [between endometriosis and breast cancer] varied by tumor hormone receptor status (P value, test for heterogeneity: .001), although women with endometriosis were not at increased risk of estrogen- and progesterone receptor-positive (ER+/PR+) tumors (adjusted HR 1.00, 95% CI 0.87–1.14) or ER- and PR- tumors (adjusted HR 0.90, 95% CI 0.67–1.21).”

5. A. Twofold - According to a study published in Obstetrics & Gynecology, “[w]omen with endometriosis reported 2.87 ER+/PR- breast cancer cases per 10,000 person-years compared with women without endometriosis (1.32/10,000 person-years), which resulted in nearly a twofold increased risk of ER+/PR- breast cancers (adjusted HR 1.90, 95% CI 1.44–2.50).”

For complete information, see:

Farland LV, Tamimi RM, Eliassen AH, et al. Laparoscopically confirmed endometriosis and breast cancer in the Nurses’ Health Study II. Obstet Gynecol. 2016.128(5);1025-1031.

Topics: Women's Health

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Isadora Guggenheim, ND, RN, MS, CNS LMT, owner of Second Nature Naturopathic Care, LLC
For all appointments: Tel: 845 358-8385 Fax: 845 358-2963 drguggenheim@msn.com