Intermittent fasting diets are rapidly gaining popularity.
Are they worth the hype? While there has been plenty of observational research pointing out the correlation between fasting and positive health outcomes, there is still little understanding of underlying biological mechanisms causing this.
A recent study from Harvard researchers has now shown that fasting can increase lifespan, slow aging and improve health by altering the activity of mitochondrial networks within our cells.
"Although previous work has shown how intermittent fasting can slow aging, we are only beginning to understand the underlying biology," says William Mair, senior author on the study. (Haridy, 2017)
The Harvard research shows that changing the shapes of mitochondrial networks can affect longevity and lifespan and more importantly, how fasting manipulates mitochondrial networks to keep them in a "youthful" state.
Mitochondrial cells alternate between two states, fused and fragmented. Using nematodes, researchers found that restricted diets promoted homeostasis in mitochondrial networks, allowing for a healthy plasticity between these fused and fragmented states. The worm's lifespan was increased and these results help to shed light on how fasting can increase longevity and promote healthy aging.
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"Our work shows how crucial the plasticity of mitochondria networks is for the benefits of fasting. If we lock mitochondria in one state, we completely block the effects of fasting or dietary restriction on longevity," says Mair. (Haridy, 2017)
It was also found that fasting enhances mitochondrial coordination with peroxisomes, a type of organelle that can increase fatty acid oxidation, a fundamental fat metabolism process.
"Low-energy conditions such as dietary restriction and intermittent fasting have previously been shown to promote healthy aging. Understanding why this is the case is a crucial step toward being able to harness the benefits therapeutically," explains Heather Weir, lead author of the study. (Haridy, 2017)
For many people finding a safe and effective diet that works for them can be difficult. Crash diets are unhealthy and rarely yield permanent results, fasting can be very dangerous in some individuals, and calorie-restriction can be difficult to maintain and see results quickly.
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Haridy, R. (2017, November 06). Harvard study uncovers why fasting can lead to a longer and healthier life. Retrieved from https://newatlas.com/fasting-increase-lifespan-mitochondria-harvard/52058/