Second Nature Care Blog

Low-Calorie Sweeteners Cause Weight Gain and Increase Your Risk of Stroke and Dementia

[fa icon="calendar'] Apr 21, 2017 4:29:41 PM / by Isadora Guggenheim


A recent study shows the consumption of low-calorie sweeteners allows more glucose to enter the fat cells. 

The sweeteners are associated with the upregulation of gene expression for glucose transporters in experiments using human mesenchymal stromal cells and adipose tissue. This effect was seen to be strongest in individuals with obesity. 

Using human subcutaneous fat tissue from individuals who consumed low-calorie sweeteners, the researchers showed that these cells had at least double the over expression of glucose transporters. Also over expressed were sweet taste receptors and adipogenic genes (obesity genes). 


The adipose tissue biopsies were examined for mRNA expression of adipogenic genes, as well as for glucose transporters and inflammatory markers. In individuals with low-calorie sweetener exposure, the glucose transporter GLUT1 was over expressed by 2- to 2.2-fold, while the glucose transporter GLUT4 was over expressed by a factor of 2.7-4.3.

In addition, low-calorie sweetener consumption was associated with up to 2.5-fold over expression of the sweet taste receptor TAS1R3. Sweet taste receptors are G protein–coupled receptors that are present in taste buds and in other tissues, serving as carbohydrate sensors. Adipogenic genes were also over expressed; a 1.5- to 2.4-fold increase was seen in PPARG, for example.

The study supports the theory that low-calorie sweeteners are promoting additional fat formation by allowing more glucose to enter the cells and promote inflammation which may be even more detrimental to obese individuals. This inflammation can affect cardiac function and cause neuroinflammation associated with dementia, Alzheimer's and other neurological disorders.

If you are struggling with your weight or just want help being the healthiest you, we understand your dietary and nutritional needs. 

We offer the HCG diet. It is a safe, natural and effective way to not only help you shed the pounds but to get your diet cleaned up and start you on the right path to eating healthy and feeling good. 

The HCG diet improves glucose homeostasis and increases expendable energy. HCG allows the body to sculpt and reduce abnormal fat stores under the arm, belly, buttock and inner thigh without giving you that sunken cheek look.  

The HCG diet is the original anti-inflammatory diet so patients report the elimination of joint pain, more energy and we see normal blood glucose levels and better lipid profiles. We see both men and women for HCG weight loss.  We offer a hands-on program to guide you through every day. We offer additional medicines to eliminate weight loss barriers. Book your HCG consult this week. 

The brain does regulate eating and most obese individuals have micro scarring on their hypothalamus which creates a dysregulation.  The HCG diet goes around this impairment in the hypothalamic tract and corrects issues in the dicenphalon so that you can experience normal metabolic regulation. You feel full and don't crave carbs. Ask me about the HCG diet and find out if it's right for you.  On average, our patients lose between 25 and 35 pounds in 40 days.

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Topics: Weight Loss and Obesity

Isadora Guggenheim

Written by Isadora Guggenheim

Isadora Guggenheim, ND, RN, MS, CNS LMT, owner of Second Nature Naturopathic Care, LLC
For all appointments: Tel: 845 358-8385 Fax: 845 358-2963