Second Nature Care Blog

Messengers in Saliva Regulate Bacterial Growth - Periodontal Pathogen Nosode drops,

[fa icon="calendar'] May 21, 2018 11:22:38 PM / by Winter Ninivaggi


A new UCLA-led study provides clear evidence that cellular messengers in saliva may be able to regulate the growth of oral bacteria responsible for diseases such as periodontitis (gum inflammation) and meningitis.

Periodontal disease is the inflammation and damage of the tissues and structures that surround and support the teeth.

This is the result of the colonization of pathogenic bacteria in the mouth. The disease can also effect the host on a systematic scale, as a consequence, many other chronic diseases have been correlated with unhealthy mouths.

"RNA acts as a messenger that transports DNA's instructions to other parts of the cell. Small regulatory noncoding RNAs, known as sRNAs, regulate our genes. A new class of sRNAs has also been discovered called tsRNA, which is transfer RNA-derived small RNA. tsRNA is found in human body fluids, including blood, tears and saliva."

The researchers from the study analyzed the salivary sRNAs and found that many belong to tsRNA matching the partial transfer RNA sequences of several Gram- negative oral bacteria. The bacteria have a highly toxic outer layer that can cause periodontal disease.  The salivary tsRNAs could potentially affect bacterial tRNA a type of RNA molecule that helps decode a messenger RNA sequence into a protein and is required for bacterial growth.

The study provides a evidence of a clear channel of communication between RNA messengers and bacteria in the mouth. Another significant study finding was the majority of tRNA bacteria sequences that show high sequence similarity with salivary tsRNAs came from antibiotic-resistant Gram-negative bacteria.  This observation can lead to a better understanding of oral disease and potentially open doors for prevention and treatment of periodontal diseases. 

Oral bacteria and toxins can sneak into the bloodstream and have been found in systemic sepsis, infective endocarditis, lung infections and liver disease. Periodontal disease has also been linked to rheumatoid arthritis.

Taking the best care of your oral microbiome possible is the best way to take avoid periodontal disease. Regular dental cleanings and standard daily hygiene procedure is necessary, thorough brushing and flossing is imperative . Diet is also important, a reduced intake of sugars helps to maintain a more alkaline environment.

At Second Nature Care we pay special attention to overall health. We offer natural treatment for Periodontal Disease. We offer comprehensive labs to identify inflammatory markers and those inflammatory markers that affect your cardiovascular system.

We have all natural Periodontal Pathogen Nosode drops. They work to improve resistance and treat the disease. Probiotics are also important in maintaining the oral microbiome as they are with any other microbiome.

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Topics: Body Health

Winter Ninivaggi

Written by Winter Ninivaggi

Isadora Guggenheim, ND, RN, MS, CNS LMT, owner of Second Nature Naturopathic Care, LLC
For all appointments: Tel: 845 358-8385 Fax: 845 358-2963