Your health starts in your gut.
The gut microbiome is the hub of health in the body. Study findings have suggested that Clostridium perfringens in the gut microbiome is involved in MS pathogenesis. Implicated epsilon toxin-producing Clostridium perfringens are involved in MS pathogenesis. The authors isolated ETX-producing Clostridium perfringens Type B from the stool of an MS patient and found that 10% of their MS patients had ETX-specific antibodies compared to only 1% of controls, indicating increased immune system exposure to ETX.” In MS immunopathogenesis, gut microbiota may contribute to MS immunopathogenesis by directing differentiation of CD4+ T-cell phenotypes or impacting T-regulatory cell function.
Dramatic depletion in Bacteroidetes presence is a consistent study finding in patients with MS. "According to information cited in a review article published in Multiple Sclerosis Journal, “[t]he depletion of butyrate-producing bacteria observed in MS is also seen in Clostridium difficile infection and is replenished after [fecal microbiota transplantation],” and “[u]nlike Clostridium difficile infection, large shifts in gut microbial community composition have generally not been observed in MS. Instead, enrichment or depletion of a limited number of taxa seems to be a reproducible finding.”
It sheds light on how much the gut really affects the immune system, which can then affect the brain. This could also lead to ways of diagnosis and treatment.
New Findings for MS and Cancer
Multiple Sclerosis and Gut Health
For complete information, see:
Budhram A, Parvathy S, Kremenchutzky M, Silverman M. Breaking down the gut microbiome composition in multiple sclerosis. Mult Scler. 2017;23(5):628-636.