What are CD69 receptors and what do they have to do with psoriasis? Researchers identified CD69 leukocyte activation receptors were in inflammatory skin cells linked to psoriasis, but they were not clear about their role.
Lab mice deficient in CD69 receptors and wild type mice were injected with a pro-inflammatory cytokine interluekin 23 (IL-23) to produce a psoriasis-like inflammatory reaction. In the CD69 deficient mice, they had much less swelling, inflammation and psoriatic plaque proliferation than the wild mice. The absence of CD69 showed that these receptors had an immunomodulary effect.
CD69 receptors in the cell membrane with L-type amino acid transporter 1 or LAT1 would grab tryptophan, an amino acid, and increased levels of circulating tryptophan favored psoriasis development because it increased levels of Interleukin 22 (IL-22) in the skin.
While modern medicine has no cure for psoriasis, at Second Nature we make dietary changes, correct gut imbalances, address genetic differences, use I.V. ozone with specially formulated medicines from Germany to immunomodulate psoriasis and teach stress reduction to calm the immune system from a pro-inflammatory state to a relaxed state.
