Restless leg syndrome in women.
RLS affects approximately 2.5% of adults in the United States and Northern Europe. Among adult patients RLS features “higher prevalence in women and with increasing age. RLS “is a movement disorder characterized by an urge to move the legs or arms, commonly in response to uncomfortable dysasthesia.” RLS is classified as primary or secondary in origin, with secondary RLS attributed to co morbid iron deficiency, end-stage renal disease or ESRD and pregnancy.
A large study including 57, 417 women from the Nurses' Health Study without Cancer, renal failure, and CVD at baseline. The study found that women with RLS had a higher cardiovascular disease mortality rate which may not be fully explained by common co-occurring disorders of RLS. There was no significant association between presence of physician-diagnosed RLS and high risk of total mortality only with CVD mortality.
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Li Y, Li Y, Winkelman JW, et al. Prospective study of restless legs syndrome and total and cardiovascular mortality among women. [Published online ahead of print December 15, 2017]. Neurology. doi:10.1212/WNL.0000000000004814.