Second Nature Care Blog

T Cells and Inflammatory Weight Gain

[fa icon="calendar'] Nov 17, 2016 5:00:00 AM / by Winter Ninivaggi


Cells are discovered that activate inflammatory weight gain


Researchers in Japan have discovered a subset of CD4+ T cells that are highly likely to be involved in the chronic inflammation that occurs in obesity and is also linked to cardiovascular disease and metabolic disease.

The scientists used mice to test the relationship. Compared to lean mice, overweight mice on a high-fat diet had more than twice as many CD44hi CD62Llo CD4+ T cells in their visceral fat.

They reported that when under T cell receptor stimulation the cells produced high amounts of the pro-inflammatory cytokine osteopontin. which suggests these cells play a significant role in inducing visceral adipose tissue inflammation and metabolic disorder via secretion of large amounts of OPN.

It also plays a role in insulin resistance under high-fat conditions.  This could provide a cellular target for controlling immunometabolic anomalies in visceral obesity.

These mice with the higher mean body weight showed not only signs of insulin resistance, but also glucose intolerance and chronic inflammation. When the T cells were implanted into the normal weight mice they showed these same symptoms. Further research will be conducted to discover methods of eliminating these cells and whether diet can reverse the T cell senescence in obese and diabetic animals.

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Topics: Weight Loss and Obesity

Winter Ninivaggi

Written by Winter Ninivaggi

Isadora Guggenheim, ND, RN, MS, CNS LMT, owner of Second Nature Naturopathic Care, LLC
For all appointments: Tel: 845 358-8385 Fax: 845 358-2963