Temperature Effects on MS

Correlation between MS and high temperatures. 

In a recent study, it was uncovered that MS mortality rates in the northern states of the United States is more than three times higher than that in the southern states. MS mortality rates correlate significantly and inversely with temperatures in the 48 states. Duration of sunshine hours and solar radiation do not correlate significantly with MS mortality rates. Moreover, the study found “significant correlation between isopleth maps of growth rates of MS mortality…and isopleth maps of temperature rises. Inverse correlation between MS incidence–prevalence rates and latitudes was reported in many places, including the United States, Australia, and European countries. Even though MS mortality rates are correlated with the latitudes at about the same correlation level, it is clear that the iropleth lines of MS mortality rates follow more closely with the isopleth lines of temperature than with latitude lines. There is ample evidence supporting the beneficial effect of vitamin D for MS patients.  It is well known that MS patients are very sensitive to heat events, including hot water bath, high outdoor temperatures, and exercise-induced hyperthermia. However, most of the heat-related detrimental effects for MS patients are from short-term exposures.

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1. In the United States, MS mortality rates in the northern states are approximately __________ those in the southern states.

A. Half
B. Twice
C. More than three times

2. According to a study of the 48 contiguous states, MS mortality rates correlate significantly with __________.

A. Duration of sunlight hours
B. Solar radiation exposure
C. Temperature
D. None of the above

3. True or False. The inverse correlation found between MS prevalence rates and location latitude is stronger than the correlation found between MS prevalence rates and temperature.

A. True
B. False

4. Which of the following statements is/are TRUE regarding vitamin D and MS?

A. There is an association between MS prevalence and vitamin D deficiency
B. There is evidence supporting the beneficial effect of vitamin D for MS patients
C. A and B
D. None of the above

5. True or False. Detrimental effects for MS patients related to heat usually arise from long-term exposure.

A. True
B. False

Answer Key:

1. C. More than three times

2. C. Temperature

3. A. True

4. B. There is evidence supporting the beneficial effect of vitamin D for MS patients

5. B. False

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For complete information, see:

Sun H. Temperature dependence of multiple sclerosis mortality rates in the United States. [Published online ahead of print January 12, 2017]. Mult Scler. Accessed January 30, 2017.