Second Nature Care Blog

Thyroid Hormones and Cancer

[fa icon="calendar'] Oct 3, 2016 5:00:00 AM / by Isadora Guggenheim & Winter Ninivaggi

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Higher thyroid hormone levels are associated with increased cancer risk. Each unit of free thyroxine (FT4) was associated with a 42% increase in risk for any solid cancer. It was also linked to lung and breast cancer. Higher FT4 levels were associated with significantly higher levels of solid, lung and breast cancer risk.

Factors such as age, sex, socioeconomic status, alcohol consumption, smoking, body-mass index, hypertension, diabetes and serum cholesterol were accounted for, and no association was found between thyroid stimulating hormone and any type of cancer.

There are a few molecular pathways that could provide an explanation to the link between thyroid hormones and cancer, these include :

"• The binding of thyroid hormones to their receptors can activate the oncogenic
phosphatidylinositol-3-kinase (PI3K) pathway, independent of DNA binding. Thyroid hormones can
also bind the protein integrin αvβ3, which leads to activation of the PI3K pathway.
 
• Thyroid hormones have been found to stimulate expression of the
programmed death-ligand 1 (PD-L1) gene. This gene plays a key role
in protecting cancer cells from T-cell mediated destruction.
 
• Thyroid hormones decrease expression of tumor necrosis factor (TNF)-α and
the FAS ligand; both are cell surface factors that activate apoptosis of cancerous cells.
 
• Finally, thyroid hormones can alter the expression level of cyclin
D1, a protein that regulates the cell cycle, and of cyclin dependent kinases, leading to
various tumor types, such as breast cancer and neural cancers."
 
Because the study only looked at thyroid hormone levels at baseline the researchers were unable to assess a link between changes in hormone level and cancer risk.
 

If you are currently living with a thyroid condition we offer full testing panels and individualized treatment options for your thyroid condition at Second Nature in CT. We find the "root cause of your disease" so we can reverse it.  We prescribe Nature-Throid and WP Thyroid - the best natural T3 and T4 hormone replacement.  Gluten and corn-free, no artificial colors and no FDA recalls, our medication contains natural T3, T4, thyroid co-factors T1, T2, calcitonin and iodine.

Natural forms are better and our patients feel great. Their bodies know the difference synthetic and natural. Call us if you want to look and feel your best.
 
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Topics: Healthy Living

Isadora Guggenheim, ND, FNP, RN, MS, CNS, LMT, owner of Second Nature Naturopathic Care, LLC
For all appointments: Tel: 845 358-8385 Fax: 845 358-2963 drguggenheim@msn.com