"The O2-O3 therapy is a non-invasive, non-pharmacological, no-side effect and low-cost procedure applied in medicine for the treatment of more than 50 pathological processes, whose alterations in endogenous oxidative-antioxidative balance play a crucial role . Different clinical trials evidenced the effectiveness of this therapy in the treatment of degenerative disorders such as multiple sclerosis (Smith et al., 2017, Delgado-Roche et al., 2017, Ameli et al., 2019), but also cardiovascular, peripheral vascular, neurological, orthopedic, gastrointestinal and genitourinary pathologies (Bocci, 2011, Elvis, Ekta, 2011, Re et al., 2008, Bocci, 2012, Smith et al., 2017, Braidy et al., 2018); fibromyalgia (Moreno -Fernandez et al., 2019, Tirelli et al., 2019); skin diseases / wound healing (Fitzpatrick et al., 2018, Wang, 2018); diabetes / ulcers (Martinez-Sanchez et al., 2005, Guclu et al. ., 2016, Rosul, Patskan, 2016, Izadi et al., 2019, Ramirez-Acuna et al., 2019); infectious diseases (Smith et al., 2017, Mandhare et al., 2012, Song et al., 2018), including the recent global pandemic disease of coronavirus disease 2019 (COVID-19) (Zheng et al., 2020); dentistry (Isler et al., 2018, Khatri et al., 2015, Srikanth et al., 2013, Azarpazhooh et al., 2009); lung diseases (Hernandez Rosales et al., 2005); osteomyelitis (Bilge et al., 2018). The potential role of O2-O3 as an adjuvant therapy for cancer treatment has been also suggested in in vitro and animal studies as well as in isolated clinical reports (Clavo et al., 2018).
At present, we have commenced a randomized double-blind clinical trial with the aim to test the efficacy of this therapy in a cognitive frailty cohort, a grant approved by the Italian Minister of Health (RF-2016-02363298). This pilot study will permit to validate the O2-O3 therapy in an early phase of cognitive decline, when it is still possible to intervene, before to develop a potential neurodegenerative pathology.
To date, the O2-O3 therapy acquires a further prestigious significance, after the medicine Nobel prize for "discovery of how cells sense oxygen" in 2019. Indeed, O2 is the most vital element required for human life and it is the key to good health; O3 is O2 with an extra molecule added. The O2 availability affects genes expression of different factors (HIFs, Hypoxia Inducible Factors), leading to the activation of trophic proteins (VEGF, Vascular Endothelial Growth Factor; PDGF, Platelet-derived growth factor) and consequently to specific biological processes, including erythropoiesis, angiogenesis and anaerobic glucose metabolism (Zhou et al., 2019). O3 plays a role of cellular adapter to hypoxia, because it is well known its effects in increasing the levels of VEGF, PDGF, HIF (Curro et al., 2018, Zhang et al., 2014, Re et al., 2010), exactly as the cell does when there is no O2 available ".
Vascular health is the cornerstone of Longevity medicine. Vascular health parallels aging. Aside from the global pandemic, the leading cause of mortality and morbidity is still cardiovascular disease. As we age, so do our vessels.
Alzheimer's disease or commonly called AD is a progressive disease usually affecting people over 60 years of age. AD is responsible for 75% of all dementia and is the most aggressive neurodegenerative disease. Researchers and clinicians see a build-up of beta-amyloid protein in the brain.
"Approximately 60% of children diagnosed with ADHD continue with the disorder into adulthood."
Are you like this some days? Or maybe more compassionate than these two knuckleheads.
Are you empathetic or aggressive or both? Researchers found that brain chemicals, oxytocin and vasopression, are the biochemical links between empathy and aggression.
Do pesticides cause depression and and increase the risk of suicide? Why are non-organic farmers 3.6 times more likely to commit suicide than other professions?
Looking for mental and physical energy? Do you need to focus better and don't want to take addictive Big Pharma Ritalin?
Do you need a super power to stop an addiction? Can you curb a craving with your thought alone?
We offer 3 tools that reduce cravings, improve the brain function and turn the "dirty genes" off.
Is this you at night? Do you have a hard time getting to sleep or staying asleep?
Over time, your brain is shrinking because of insomnia. Find out how to fix this.
It's not just a gut feeling. There is tangible evidence that CFS Chronic Fatigue Syndrome is either accompanied or caused by gram negative enterobacteria that migrates through the gut wall. Normally kept in check by tight gap junctions in the intestines, these enterobacteria translocate easily through a permeable mucosa membrane causing elevated IgM and IgA markers for endotoxins in the blood. This in turn causes systemic oxidative stress.