MEDICAL OZONE for LIFE

The adoption of oxygen ozone therapy to treat patients severely affected by Covid, as a medical practice to be used for compassionate use, has become the subject of public debate in Spain.

The story that sparked the discussion concerns Juan Francisco Martí Piqueres, struck by Covid and hospitalized at the Hospital de La Plana in Castellón (Spain).

When the medical management of the hospital announced that Juan Francisco was dying, his wife Vanessa had chosen to attempt oxygen/ozone therapy and, faced with the refusal of the health authorities, she turned to the judiciary.

The fact that a court in Castellón forced the Hospital de La Plana to allow the entry of doctors experienced in ozone therapy to treat a patient in critical condition has triggered a series of reactions and statements. Various groups and professional associations protested against a supposed judicial interference in the medical field.

These associations have argued that ozone therapy has no “scientific evidence” and that it is a sort of “pseudo therapy”, despite the fact that it does not appear in the list of pseudo-therapies issued by the Ministry of Health, and despite the fact that Juan Francisco Martí Piqueres is cured thanks to the applications of oxygen ozone.

In this context, 10 authoritative doctors and professors of international fame have taken the trouble to examine the scientific literature on ozone therapy, to determine the degree of “scientific evidence” and possible evaluation as “pseudo therapy”. Their names are: Luis Prieto Valiente, Manuel Calleja Hernández, Domingo Ortega Alcalde, Vicente Navarro López, Juan José Bestard Perelló, Blas García Medina, David Prieto Merino, Carlos Álvarez Leiva, Eduardo Valencia Laseca, Juan Alguersruari Bess.

The 10 aforementioned doctors have drawn up a document entitled “Ozone is Not a Pseudotherapy” in which they specify that “there is considerable evidence published internationally on the efficacy and safety of ozone therapy for various diseases” and that “to disqualify a the whole line of research is an irresponsibility that can condemn countless present and future patients”.

A simple search on the term “ozone therapy” carried out on the PubMed platform shows that there are 3,966 articles indexed and published in authoritative medical and scientific journals.

The authors of the paper refer to the “meta-analysis” of published works, explaining that meta-analyzes are studies that gather and analyze data from the most relevant studies, and that their results are considered more truthful than any other single study.

The “meta analysis” studies – say the aforementioned doctors and professors – are obviously much more relevant even than a communication from a professional association, which is not subject to a review process, lacks clear authorship and is not potentially free of conflicts of interest: ground rules of any rigorous audit process.

The “meta analysis” referred to was published in the “Journal Vascular and Interventional Radiology” (JVIR), a high-impact journal that includes 12 studies involving a total sample of 8,000 patients with herniated discs. In these studies it is concluded that “treatment with ozone and oxygen is an effective and extremely safe treatment” and that “the estimated improvement in pain and function is impressive”, considering that the treatment is effective in a sample that includes patients among the 13 and 94 years with all types of herniated discs.

https://pubmed.ncbi.nlm.nih.gov/20188591/

None of the studies reviewed claims that ozone therapy lacks “scientific approval” or anything like that.

Many of the studies on ozone therapy are published in high-impact journals of proven quality and rigor, among the most respected in the panoply of scientific journals.

Once it has been demonstrated that ozone “is not a pseudo therapy”, the authors of the document ask themselves the question “Does ozone therapy have the potential to effectively treat Covid patients?”.

After analyzing 11 publications – mostly observational studies or series of clinical cases – the doctors and teachers conclude that “no adverse effects are observed in any of them. Moreover, some positive effects are evident but need further randomized controls and clinical tests”. And they add that, in any case, “further research should be encouraged until it is possible to verify how effective ozone therapy is in treating Covid patients”.

For this reason, the authors of the document “El ozono no es una pseudoterapia” invite you to practice oxygen ozone therapy “especially when the patient is in a situation with little chance of survival”.

In this perspective, the “Clinical Trials” website reports 9 different studies on Covid patients, in the different stages of development of the disease, treated and cured with ozone therapy.

Among the most complete studies on the efficacy of ozone therapy in the treatment of Covid, cited by the signatories of the document, is the one entitled “Recent case studies on the use of ozone to combat coronavirus: Problems and perspectives”, published by the researchers University of Ohio (USA) and University of Bangalore (India):

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7733684/

The 10 medical authors of the document drawn up in Spain reiterate that it is irresponsible to disqualify an entire line of research without confronting the published studies on the subject, and recall that “it is not up to associations or professional colleges to establish scientific truth or evidence, but rather to universities, hospitals and research centers through studies and publications of proven scientific validity”.

The signatories of the document in question are:

- Luis Prieto Valiente. Doctor of medicine (biostatistics), postdoc at the University of Oxford. He was professor of biostatistics applied to medical research at the Complutense University of Madrid, the Autonomous University of Madrid and the Carlos III Institute. He is the founder of the first Medical Biostatistics Service of a Spanish hospital and has more than 200 scientific contributions published in medical journals and congresses. He is currently professor of research methodology at UCAM.

- Manuel Calleja Hernández. Graduated in Medicine from the Complutense University of Madrid, MIR from the Autonomous University of Madrid. Fellow at the European Board of Cardiothoratic Surgery (EBCTS). He was the youngest cardiovascular surgery specialist with a position in the Spanish public health system, with training in hospitals in the United States and England. He is a former head of service in three Spanish public hospitals and author of over 30 articles in scientific journals, 200 contributions to medical conferences and five books as a co-author.

- Domingo Ortega Mayor. Graduated in medicine from the University of Barcelona. Nuclear Medicine Specialist. Former head of the Nuclear Medicine service at the Vall d’Hebrón Hospital in Barcelona. Member and secretary for more than fifteen years of the Deontological Commission of the College of Doctors of Barcelona.

- Vicente Navarro López. Doctor of Medicine and Extraordinary Doctorate from the Miguel Hernández University of Elche. Associate Professor and Director of the Chair of Human Microbiota, as well as Principal Investigator of the Mibiopath group at the Catholic University of San Antonio de Murcia (UCAM). Member of the scientific committee of the Spanish Journal of Chemiotherapy and of the Microorganisms journal. Author of over 100 books, chapters and scientific publications in the field of infectious diseases and the microbiota.

- Juan José Bestard Perello Lawyer specializing in health law. Specialist in preventive medicine and public health. Johns Hopkins U. Health Economics graduate. He works in public health and law practice. He is Co-president of the health law section of ICAM. With an extensive curriculum in health management. Author of several books.

- Blas García Medina. Doctor of Medicine. Visiting professor for 25 years at the Department of Surgery and its specialties at the University of Granada. Head of the Maxillofacial Surgery Service at the Virgen de las Nieves University Hospital from 2007 to 2018.

- David Prieto Merino. Doctor of Social and Health Sciences at the University of Alcalá, where he was associate professor of biostatistics for ten years. He is currently full professor of biostatistics and epidemiology at the London School of Hygiene & Tropical Medicine and director of the International Chair of Statistical Analysis and Big Data at the Catholic University of Murcia. He is also an honorary professor at the Institute of Health Informatics at University College London and was associate editor of the International Journal of Epidemiology.

- Carlos Alvarez Leiva. Doctor of Medicine, specialist in intensive medicine. Founder and director of the SAMU Group, the first emergency service with UVI-mobile in Spain. International expert in Crisis Management. Promoter of the European Council of Disaster Medicine.

- Eduardo Valencia Laseca. Former head of the maxillofacial surgery service of the Virgen de las Nieves university hospital, Granada. Former President of the National Society of Head and Neck Surgeons. Former president of the National Society of Aesthetic Surgeons.

- Juan Alguersuari Bes. Doctor, president of the Juaneda Assistance Network, the main private hospital network in the Balearic Islands, with 5 hospitals, 30 health centers and 1,500 dependent employees.

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