New rheumatoid arthritis discovery.
A team of researchers in the United States discovered a novel mechanism in which a key protein drives the inflammatory damage associated with rheumatoid arthritis. This discovery can lead to entirely new ways of treating the autoimmune disease affecting so many.
Finding an immune cytokine called tumor necrosis factor-alpha (TNF-alpha) plays a crucial role in joint tissue inflammation. TNF inhibitors offered RA patients a new type of medicine following its discovery. While this was a break through for many, TNF inhibitors are not effective in all patients, additionally, they are not good long term medicines due to a variety of side effects according to the senior author, Salah‑Uddin Ahmed, of the new research study.
“Tumor necrosis factor‑alpha – or TNF‑alpha for short – is one of the main inflammatory proteins that drive rheumatoid arthritis and is targeted by many currently available therapies,” said Ahmed. “However, over time patients can develop a resistance to these drugs, meaning they no longer work for them. That is why we were looking for previously undiscovered drug targets in TNF‑alpha signaling, so basically proteins that it interacts with that may play a role.” (CITATION HERE)
The new research focused on a type of human cell called synovial fibroblasts. These are cells that line joints. In cases of RA, inflammation in synovial fibroblasts is triggered by TNF-alpha.
In looking for a protein that plays a role in joint inflammation the researchers homed in on a molecule called sulfatase‑2. Prior cancer studies have indicated sulfatase‑2 plays a role in tumor growth, and it's known to be involved in immune cell signaling processes."
The researchers hypothesized sulfatase‑2 could play a part in the way TNF-alpha triggers inflammation. To test this, the team removed the protein from synovial fibroblasts and then watched what happened when the cells were stimulated with TNF-alpha. The experiments revealed significantly reduced inflammatory responses in the cells when sulfatase‑2 was removed.
It’s important to note this research is still in very early stages.
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Autoimmune Arthritis Natural Treatment
(2022, September 8). Rheumatoid arthritis protein discovery points to potential new therapy. New Atlas. Retrieved September 13, 2022, from https://newatlas.com/medical/rheumatoid-arthritis-protein-discovery-tnf-sulfatase/?utm_source=New%2BAtlas%2BSubscribers&utm_campaign=d87e435089-EMAIL_CAMPAIGN_2022_09_09_01_50&utm_medium=email&utm_term=0_65b67362bd-d87e435089-76698122