What is the culprit of Macular Degeneration?
Researchers at the University of Virginia School of Medicine have discovered a critical trigger for the damaging inflammation that robs millions of their site. This finding may lead doctors to being able to potentially stop macular degeneration before it occurs.
Oxidative Stress/Free Radicals that cause Inflammation
“Almost 200 million people in the world have macular degeneration. If macular degeneration were a country, it would be the eighth-most-populated nation in the world. That’s how large a problem this is,” said Dr. Jayakrishna Ambati vice chairman for research of UVA’s Department of Ophthalmology and the founding director of UVA’s Center for Advanced Vision Science.
They learned that the culprit is an enzyme called cGAS. It plays a role in the body's immune response to infections by detecting foreign DNA. It accounts for 85-90% of all macular degeneration cases. They found that it has nothing to do with a virus or bacteria that activates the cGAS, leading to the killing of cells in the retina and ultimately blindness. "The enzyme may also play important roles in conditions such as diabetes, lupus and obesity, and researchers already are working to create drugs that could inhibit its function."
Macular degeneration affects between 30-50 million people worldwide.
Risk factors for Macular Degeneration Include
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UVA Discovers Trigger for Macular Degeneration That Robs Millions of Vision. (2017, November 27). Retrieved January 30, 2018, from https://news.virginia.edu/content/uva-discovers-trigger-macular-degeneration-robs-millions-vision