Second Nature Care Blog

Your Gut - The Sistine Chapel - Gut Restoration - Good Gut Products

[fa icon="calendar'] Aug 19, 2015 6:58:42 AM / by Dr. Isadora Guggenheim

Good Health begins with Good Gut Products www.secondnaturecare.com

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Michelangelo's Sistine Chapel took time to restore just like the restoration of your intestinal microbiome. You can manipulate your gut flora and tighten the interepithelial junctions with probiotics.  Probiotics are live therapeutic microorganisms have a beneficial effect on the intestinal mucosa through several mechanisms.  Like a restorative paintbrush, probiotics inhibit pathogens from adhering to the gut wall, they make the epithelium wall stronger and less permeable and they keep the immune system in check.  The microbiota becomes stable and normal fermentation takes place.  Probiotic bacteria secrete short chain fatty acids that lower the pH in the gut and produce proteins that destroy un-friendly bacteria.  Butyric acid, a by product from the bacterial fermentation of fiber, is soul food for the colonic cells.  This supports gut cell integrity. Lactobacillus, Streptococcus, Bifidobacteria  and yeasts such as  Saccharamyces boulardii  are all in the family of probiotics that improve bowel function. 

Studies have shown that probiotics positively influence mood regulation in Chronic Fatigue patients.  

Bifidobacterium infantis boosts serotonin levels in the brain that are associated with anxiety and depression. Bifidobacteria  has been well-studied and found to correlate with a significant reduction in oxidative and inflammatory stress markers. 

What about all of this inflammation?  Does inflammation cause Chronic Fatigue Syndrome? 

A better explanation might be that there is an alteration in the intestinal microbiome that becomes more fertile for pathogens to set up camp and those pathogens create low grade inflammation and cause peripheral pro-inflammatory signaling throughout the body.

Those signals can lead to vascular disease, metabolic disease, mood disorders and dementia.  It was thought that CFS patients were immunosuppressed, but it is more probable that the innate immune system is hyper-responsive or turned on and can't turn off so it produces high levels of C-reactive protein.  Think of a pin stuck in a doorbell.  The doorbell can't turn off unless someone releases the pin.  All you can hear is the frequency of the doorbell ringing.  It's almost as if this frequency calls other viruses out of dormancy and various antibodies come into action.  This whole "call to arms" becomes exhausting for the host. 

Treatments have focused on quieting these pro-inflammatory chemicals - interleukin-1, tumor necrosis factor-alpha and interleukin-6.  How does inflammation effect the gut?  Details, details. 

The enteric nervous system or ENS is responsible for the intrinsic innervation of the bowel.  It regulates the intestinal mucosa and supervises activities in the whole G.I. tract.  The ENS functions under the autonomic nervous system and is independent of the central nervous system.  There are two major nerve centers in the gut.  One is called Auerbach's in the muscles and the other is called Meissner's that lives in the submucosa.  These nerve centers send and receive messages, crank the muscles into action and talk to each other through intestinal microcircuits.  When there is gut inflammation whether permanent or transient the ENS can disrupt normal G.I. functions.  Muscular movements and secretions involved in nutrient absorption are changed.  When the intestines becomes inflamed nerves get damaged so neurotransmitters or brain chemicals form differently and the system gets flooded with WBC's that rush in to assess the cellular scene.  This results in motility issues, pain, and gut dysfunction well after the inflammatory event has been resolved.   

Chronic fatigue syndrome is characterized by increased oxidative stress.  Chronic autoimmune disease patients have lower levels of a major antioxidant in the body called L-Glutathione.  L-Glutathione is rapidly depleted by oxidative stress and this deficiency creates more oxidative stress and disease progression.  A vicious cycle ensues.  We all have oxidative stress from the foods we eat and environmental exposures, but our body maintains a balance when an ROS or reactive oxygen species is formed then our tissues produce more antioxidants to fight the fire.  Sometimes the fire becomes overwhelming when persistent chronic oxidative stress depletes our antioxidant stores.  This is when we experience systemic and local tissue injury.  We don't have enough water to douse the fire.  8-OH-deoxy guanosine or 8-OHdG is a sensitive urinary marker of total oxidative stress that is produced when our DNA is being repaired.  8-OHdG becomes elevated in individuals with chronic disease.  Measuring 8-OHdG can be used as an early marker for diagnosis and to see if treatment protocols are working. It is a stand alone risk factor for disease. 

When viral or bacterial infections persist and become chronic, these reactivating infections promote ROS or reactive oxygen species and radical nitrogen species that produce pro-inflammatory chemicals that damage fatty acid membranes around all cells, proteins, DNA and the mitochondria where we produce energy.  Chronic disease makes chronic fatigue.  Immune functions become suppressed and lower natural killer cells who police the body for pathogens.    

FIGHT BACK WITH GOOD GUT PRODUCTS.

Second Nature patients fight back with GOOD GUT treatment protocols, I.V. Ozone and Vitamin C drips, Xymogen's Viragraphis, Resveratin ES, Immunotix 500, Phosphaline 4:1, Bio C and other immune bolstering I.V. cocktails.  It takes time to put the fire out just like it took time to restore the Sistine Chapel, but you can achieve 100% restoration of your health.    

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Topics: Gut Repair

Isadora Guggenheim, ND, FNP, RN, MS, CNS, LMT, owner of Second Nature Naturopathic Care, LLC
For all appointments: Tel: 845 358-8385 Fax: 845 358-2963 drguggenheim@msn.com